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I'm pretty picky about frameworks, but I've really been liking the 960 Grid System by SonSpring. It may not be appropriate for some projects and while you could probably create a cleaner code base from scratch, this small (4kb) file will make development much faster.

I've been using BluePrint CSS Framework: http://code.google.co...

I've used it on a handful of sites and have been pretty pleased with the results.